At the Viral Immunology Center at Georgia State University (GSU), Atlanta, Georgia, Tri-Stack laboratory fume hood ventilation systems solve a number of dynamic issues at Biosafety Level 4 laboratories, where sophisticated viral studies are conducted. These types of laboratories could use agents such as tuberculosis and anthrax, as well as disease-causing microorganisms (bacteria) that can be contractible by aerosol means. The 2000 sq.ft. Level 4 laboratory required a dedicated air supply and exhaust system incorporating Tri-Stack laboratory fume hood exhaust fans. The fans were scaled larger than required to assure adequate static pressure since achieving desired airflow and pressure differentials is essential when designing and building containment laboratories.